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Hawaii lawmakers raise hotel tax to help deal with climate change

ClimateWire News - Tue, 05/06/2025 - 6:09am
Experts say this is the nation's first state lodging tax that raises money for the environment and coping with climate change.

Author Correction: Heterogeneous pressure on croplands from land-based strategies to meet the 1.5 °C target

Nature Climate Change - Tue, 05/06/2025 - 12:00am

Nature Climate Change, Published online: 06 May 2025; doi:10.1038/s41558-025-02353-7

Author Correction: Heterogeneous pressure on croplands from land-based strategies to meet the 1.5 °C target

If time is money, here’s one way consumers value it

MIT Latest News - Tue, 05/06/2025 - 12:00am

As the saying goes, time is money. That’s certainly evident in the transportation sector, where people will pay more for direct flights, express trains, and other ways to get somewhere quickly.

Still, it is difficult to measure precisely how much people value their time. Now, a paper co-authored by an MIT economist uses ride-sharing data to reveal multiple implications of personalized pricing.

By focusing on a European ride-sharing platform that auctions its rides, the researchers found that people are more responsive to prices than to wait times. They also found that people pay more to save time during the workday, and that when people pay more to avoid waiting, it notably increases business revenues. And some segments of consumers are distinctly more willing than others to pay higher prices.

Specifically, when people can bid for rides that arrive sooner, the amount above the minimum price the platform can charge increases by 5.2 percent. Meanwhile, the gap between offered prices and the maximum that consumers are willing to pay decreases by 2.5 percent. In economics terms, this creates additional “surplus” value for firms, while lowering the “consumer surplus” in these transactions.

“One of the important quantities in transportation is the value of time,” says MIT economist Tobias Salz, co-author of a new paper detailing the study’s findings. “We came across a setting that offered a very clean way of examining this quantity, where the value of time is revealed by people’s transportation choices.”

The paper, “Personalized Pricing and the Value of Time: Evidence from Auctioned Cab Rides,” is being published in Econometrica. The authors are Nicholas Buchholz, an assistant professor of economics at Princeton University; Laura Doval, a professor at Columbia Business School; Jakub Kastl, a professor of economics at Princeton University; Filip Matejka, a professor at Charles University in Prague; and Salz, the Castle Krob Career Development Associate Professor of Economics in MIT’s Department of Economics.

It is not easy to study how much money people will spend to save time — and time alone. Transportation is one sector where it is possible to do so, though not the only one. People will also pay more for, say, an express pass to avoid long lines at an amusement park. But data for those scenarios, even when available, may contain complicating factors. (Also, the value of time shouldn’t be confused with how much people pay for services charged by the hour, from accountants to tuba lessons.)

In this case, however, the researchers were provided data from Liftago, a ride-sharing platform in Prague with a distinctive feature: It lets drivers bid on a passenger’s business, with the wait time until the auto arrives as one of the factors involved. Drivers can also indicate when they will be available. In studying how passengers compare offers with different wait times and prices, the researchers see exactly how much people are paying not to wait, other things being equal. All told, they examined 1.9 million ride requests and 5.2 million bids.

“It’s like an eBay for taxis,” Salz says. “Instead of assigning the driver to you, drivers bid for the passengers’ business. With this, we can very directly observe how people make their choices. How they value time is revealed by the wait and the prices attached to that. In many settings we don’t observe that directly, so it’s a very clean comparison that rids the data of a lot of confounds.”

The data set allows the researchers to examine many aspects of personalized pricing and the way it affects the transportation market in this setting. That produces a set of insights on its own, along with the findings on time valuation. 

Ultimately, the researchers found that the elasticity of prices — how much they change — ranged from four to 10 times as much as the elasticity of wait times, meaning people are more keen on avoiding high prices.

The team found the overall value of time in this context is $13.21 per hour for users of the ride-share platform, though the researchers note that is not a universal measure of the value of time and is dependent on this setting. The study also shows that bids increase during work hours.

Additionally, the research reveals a split among consumers: The top quartile of bids placed a value on time that is 3.5 times higher than the value of the bids in the bottom quartile.

Then there is still the question of how much personalized pricing benefits consumers, providers, or both. The numbers, again, show that the overall surplus increases — meaning business benefits — while the consumer surplus is reduced. However, the data show an even more nuanced picture. Because the top quartile of bidders are paying substantially more to avoid longer waits, they are the ones who absorb the brunt of the costs in this kind of system.

“The majority of consumers still benefit,” Salz says. “The consumers hurt by this have a very high willingness to pay. The source of welfare gains is that most consumers can be brought into the market. But the flip side is that the firm, by knowing every consumer’s choke point, can extract the surplus. Welfare goes up, the ride-sharing platform captures most of that, and drivers — interestingly — also benefit from the system, although they do not have access to the data.”

Economic theory and other transportation studies alone would not necessarily have predicted the study’s results and various nuances.

“It was not clear a priori whether consumers benefit,” Salz observes. “That is not something you would know without going to the data.”

While this study might hold particular interest for firms and others interested in transportation, mobility, and ride-sharing, it also fits into a larger body of economics research about information in markets and how its presence, or absence, influences consumer behavior, consumer welfare, and the functioning of markets.

“The [research] umbrella here is really information about where to find trading partners and what their willingness to pay is,” Salz says. “What I’m broadly interested in is these types of information frictions and how they determine market outcomes, how they might impact consumers, and be used by firms.”

The research was supported, in part, by the National Bureau of Economic Research, the U.S. Department of Transportation, and the National Science Foundation. 

Startup helps farmers grow plant-based feed and fertilizer using wastewater

MIT Latest News - Tue, 05/06/2025 - 12:00am

Farmers today face a number of challenges, from supply chain stability to nutrient and waste management. But hanging over everything is the need to maintain profitability amid changing markets and increased uncertainty.

Fyto, founded by former MIT staff member Jason Prapas, is offering a highly automated cultivation system to address several of farmers’ biggest problems at once.

At the heart of Fyto’s system is Lemna, a genus of small aquatic plants otherwise known as duckweed. Most people have probably seen thick green mats of Lemna lying on top of ponds and swamps. But Lemna is also rich in protein and capable of doubling in biomass every two days. Fyto has built an automated cropping system that uses nitrogen-rich wastewater from dairy farms to grow Lemna in shallow pools on otherwise less productive farmland. On top of the pools, the company has built what it believes are the largest agricultural robots in the world, which monitor plant health and harvest the Lemna sustainably. The Lemna can then be used on farms as a high-protein cattle feed or fertilizer supplement.

Fyto’s systems are designed to rely on minimal land, water, and labor while creating a more sustainable, profitable food system.

“We developed from scratch a robotic system that takes the guesswork out of farming this crop,” says Prapas, who previously led the translational research program of MIT’s Tata Center. “It looks at the crop on a daily basis, takes inventory to know how many plants there are, how much should be harvested to have healthy growth the next day, can detect if the color is slightly off or there are nutrient deficiencies, and can suggest different interventions based on all that data.”

From kiddie pools to cow farms

Prapas’ first job out of college was with an MIT spinout called Green Fuel that harvested algae to make biofuel. He went back to school for a master’s and then a PhD in mechanical engineering, but he continued working with startups. Following his PhD at Colorado State University, he co-founded Factor[e] Ventures to fund and incubate startups focused on improving energy access in emerging markets.

Through that work, Prapas was introduced to MIT’s Tata Center for Technology and Design.

“We were really interested in the new technologies being developed at the MIT Tata Center, and in funding new startups taking on some of these global climate challenges in emerging markets,” Prapas recalls. “The Tata Center was interested in making sure these technologies get put into practice rather than patented and put on a shelf somewhere. It was a good synergy.”

One of the people Prapas got to know was Rob Stoner, the founding director of the Tata Center, who encouraged Prapas to get more directly involved with commercializing new technologies. In 2017, Prapas joined the Tata Center as the translational research director. During that time, Prapas worked with MIT students, faculty, and staff to test their inventions in the real world. Much of that work involved innovations in agriculture.

“Farming is a fact of life for a lot of folks around the world — both subsistence farming but also producing food for the community and beyond,” Prapas says. “That has huge implications for water usage, electricity consumption, labor. For years, I’d been thinking about how we make farming a more attractive endeavor for people: How do we make it less back-breaking, more efficient, and more economical?”

Between his work at MIT and Factor[e], Prapas visited hundreds of farms around the world, where he started to think about the lack of good choices for farming inputs like animal feed and fertilizers. The problem represented a business opportunity.

Fyto began with kiddie pools. Prapas started growing aquatic plants in his backyard, using them as a fertilizer source for vegetables. The experience taught him how difficult it would be to train people to grow and harvest Lemna at large scales on farms.

“I realized we’d have to invent both the farming method — the agronomy — and the equipment and processes to grow it at scale cost effectively,” Prapas explains.

Prapas started discussing his ideas with others around 2019.

“The MIT and Boston ecosystems are great for pitching somewhat crazy ideas to willing audiences and seeing what sticks,” Prapas says. “There’s an intangible benefit of being at MIT, where you just can’t help but think of bold ideas and try putting them into practice.”

Prapas, who left MIT to lead Fyto in 2019, partnered with Valerie Peng ’17, SM ’19, then a graduate student at MIT who became his first hire.

“Farmers work so hard, and I have so much respect for what they do,” says Peng, who serves as Fyto’s head of engineering. “People talk about the political divide, but there’s a lot of alignment around using less, doing more with what you have, and making our food systems more resilient to drought, supply chain disruptions, and everything else. There’s more in common with everyone than you’d expect.”

A new farming method

Lemna can produce much more protein per acre than soy, another common source of protein on farms, but it requires a lot of nitrogen to grow. Fortunately, many types of farmers, especially large dairy farmers, have abundant nitrogen sources in the waste streams that come from washing out cow manure.

“These waste streams are a big problem: In California it’s believed to be one of the largest source of greenhouse gas emissions in the agriculture sector despite the fact that hundreds of crops are grown in California,” Prapas says.

For the last few years, Fyto has run its systems in pilots on farms, trialing the crop as feed and fertilizer before delivering to its customers. The systems Fyto has deployed so far are about 50 feet wide, but it is actively commissioning its newest version that’s 160 feet wide. Eventually, Fyto plans to sell the systems directly to farmers.

Fyto is currently awaiting California’s approval for use in feed, but Lemna has already been approved in Europe. Fyto has also been granted a fertilizer license on its plant-based fertilizer, with promising early results in trials, and plans to sell new fertilizer products this year.

Although Fyto is focused on dairy farms for its early deployments, it has also grown Lemna using manure from chicken, and Prapas notes that even people like cheese producers have a nitrogen waste problem that Fyto could solve.

“Think of us like a polishing step you could put on the end of any system that has an organic waste stream,” Prapas says. “In that situation, we’re interested in growing our crops on it. We’ve had very few things that the plant can’t grow on. Globally, we see this as a new farming method, and that means it’s got a lot of potential applications.”

Q&A: A roadmap for revolutionizing health care through data-driven innovation

MIT Latest News - Mon, 05/05/2025 - 4:15pm

What if data could help predict a patient’s prognosis, streamline hospital operations, or optimize human resources in medicine? A book fresh off the shelves, “The Analytics Edge in Healthcare,” shows that this is already happening, and demonstrates how to scale it. 

Authored by Dimitris Bertsimas, MIT’s vice provost for open learning, along with two of Bertsimas’ former students — Agni Orfanoudaki PhD ’21, associate professor of operations management at University of Oxford’s Saïd Business School, and Holly Wiberg PhD ’22, assistant professor of public policy and operations research at Carnegie Mellon University — the book provides a practical introduction to the field of health care analytics. With an emphasis on real-world applications, the first part of the book establishes technical foundations — spanning machine learning and optimization — while the second part of the book presents integrated case studies that cover various clinical specialties and problem types using descriptive, predictive, and prescriptive analytics. 

Part of a broader series, “The Analytics Edge in Healthcare” demonstrates how to leverage data and models to make better decisions within the health care sector, while its predecessor, “The Analytics Edge,” dives into the science of using data to build models, improve decisions, and add value to institutions and individuals. 

Bertsimas, who is also the associate dean of business analytics and the Boeing Leaders for Global Operations Professor of Management at the MIT Sloan School of Management, is the innovator behind 15.071 (The Analytics Edge), a course on MIT Open Learning’s MITx that has attracted hundreds of thousands of online learners and served as the inspiration behind the book series. Bertsimas took a break from research and his work at MIT Open Learning to discuss how the field of analytics is transforming the health care system and share some surprising ways analytics are already being used in hospitals. 

Q: How is the field of analytics changing the way hospitals provide care and manage their operations?

A: As an academic, I’ve always aspired to educate, write publications, and utilize what we do in practice. Therefore, I founded Holistic Hospital Optimization (H20) with the goal of optimizing hospital operations with machine learning to improve patient care. We have developed a variety of tools at MIT and implemented them at hospitals around the world. For example, we manage patients’ length of stay and their deterioration indexes (a computerized tool that predicts a patient’s risk of clinical deterioration); we manage nurse optimization and how hospitals can allocate human resources appropriately; and we optimize blocks for surgeries. This is the beginning of a change where analytics and AI methods are now being utilized quite widely. My hope would be that this work and this book will accelerate the effect of using these tools. 

Additionally, I have taught a nine-lecture course twice with Agni and Holly at the Hartford Hospital System, where I realized that these analytics methods — which are typically not taught in medical schools — can be demonstrated for health care practitioners, including physicians, nurses, and administrators. To have an impact, you need to have appropriate methods, implement them, and apply them, but you also need to educate people on how to use them. This links well with my role at Open Learning, where our objective is to educate learners globally. In fact, Open Learning is launching this fall Universal AI, a dynamic online learning experience that provides comprehensive knowledge on artificial intelligence, preparing a global audience of learners for employment in our rapidly evolving job market. 

Q: What are some surprising ways analytics are being used in health care that most people wouldn’t expect?

A: Using analytics, we have reduced patients’ length of stay at Hartford Hospital from 5.67 days to five days. We have an algorithm that predicts patients’ probability of being released; therefore, doctors prioritize the patients with the highest probability, preparing them for discharge. This means that the hospital can treat far more patients, and the patients stay in the hospital less time.

Furthermore, when hospitals saw an increase in nurse turnover during the Covid-19 pandemic, we developed an analytics system that takes into account equity and fairness and decreases overtime costs, giving preferred slots to nurses and decreasing overall turnover substantially. These are just two examples; there are many others where an analytical perspective to health care and medicine has made a material difference. 

Q: Looking ahead, how do you see artificial intelligence shaping the future of health care?

A: In a very significant way — we use machine learning to make better predictions, but generative AI can explain them. I already see a movement in that direction. It’s really the evolution of AI that made this possible, and it is exciting. It’s also important for the world, because of its capabilities to improve care and save lives. 

For example, through our program at the Hartford Hospital System, we discovered that a patient was getting worse and predicted through analytics that they would get even worse. After our prediction, the doctors examined the patient more closely and discovered the patient had an early case of sepsis, a life-threatening condition in which the body responds improperly to an infection. If we hadn’t detected sepsis earlier, the patient might have died. This made an actual difference in saving a person’s life. 

Q: If you had to describe “The Analytics Edge in Healthcare” in one or two words, what would they be, and why? 

A: The book is a phased transition in health care because it is capable of affecting the health care sector in a way that has not been done before. The book really outlines my work in health care and its applications in the last decade.

New tool evaluates progress in reinforcement learning

MIT Latest News - Mon, 05/05/2025 - 4:00pm

If there’s one thing that characterizes driving in any major city, it’s the constant stop-and-go as traffic lights change and as cars and trucks merge and separate and turn and park. This constant stopping and starting is extremely inefficient, driving up the amount of pollution, including greenhouse gases, that gets emitted per mile of driving. 

One approach to counter this is known as eco-driving, which can be installed as a control system in autonomous vehicles to improve their efficiency.

How much of a difference could that make? Would the impact of such systems in reducing emissions be worth the investment in the technology? Addressing such questions is one of a broad category of optimization problems that have been difficult for researchers to address, and it has been difficult to test the solutions they come up with. These are problems that involve many different agents, such as the many different kinds of vehicles in a city, and different factors that influence their emissions, including speed, weather, road conditions, and traffic light timing.

“We got interested a few years ago in the question: Is there something that automated vehicles could do here in terms of mitigating emissions?” says Cathy Wu, the Thomas D. and Virginia W. Cabot Career Development Associate Professor in the Department of Civil and Environmental Engineering and the Institute for Data, Systems, and Society (IDSS) at MIT, and a principal investigator in the Laboratory for Information and Decision Systems. “Is it a drop in the bucket, or is it something to think about?,” she wondered.

To address such a question involving so many components, the first requirement is to gather all available data about the system, from many sources. One is the layout of the network’s topology, Wu says, in this case a map of all the intersections in each city. Then there are U.S. Geological Survey data showing the elevations, to determine the grade of the roads. There are also data on temperature and humidity, data on the mix of vehicle types and ages, and on the mix of fuel types.

Eco-driving involves making small adjustments to minimize unnecessary fuel consumption. For example, as cars approach a traffic light that has turned red, “there’s no point in me driving as fast as possible to the red light,” she says. By just coasting, “I am not burning gas or electricity in the meantime.” If one car, such as an automated vehicle, slows down at the approach to an intersection, then the conventional, non-automated cars behind it will also be forced to slow down, so the impact of such efficient driving can extend far beyond just the car that is doing it.

That’s the basic idea behind eco-driving, Wu says. But to figure out the impact of such measures, “these are challenging optimization problems” involving many different factors and parameters, “so there is a wave of interest right now in how to solve hard control problems using AI.” 

The new benchmark system that Wu and her collaborators developed based on urban eco-driving, which they call “IntersectionZoo,” is intended to help address part of that need. The benchmark was described in detail in a paper presented at the 2025 International Conference on Learning Representation in Singapore.

Looking at approaches that have been used to address such complex problems, Wu says an important category of methods is multi-agent deep reinforcement learning (DRL), but a lack of adequate standard benchmarks to evaluate the results of such methods has hampered progress in the field.

The new benchmark is intended to address an important issue that Wu and her team identified two years ago, which is that with most existing deep reinforcement learning algorithms, when trained for one specific situation (e.g., one particular intersection), the result does not remain relevant when even small modifications are made, such as adding a bike lane or changing the timing of a traffic light, even when they are allowed to train for the modified scenario.

In fact, Wu points out, this problem of non-generalizability “is not unique to traffic,” she says. “It goes back down all the way to canonical tasks that the community uses to evaluate progress in algorithm design.” But because most such canonical tasks do not involve making modifications, “it’s hard to know if your algorithm is making progress on this kind of robustness issue, if we don’t evaluate for that.”

While there are many benchmarks that are currently used to evaluate algorithmic progress in DRL, she says, “this eco-driving problem features a rich set of characteristics that are important in solving real-world problems, especially from the generalizability point of view, and that no other benchmark satisfies.” This is why the 1 million data-driven traffic scenarios in IntersectionZoo uniquely position it to advance the progress in DRL generalizability.  As a result, “this benchmark adds to the richness of ways to evaluate deep RL algorithms and progress.”

And as for the initial question about city traffic, one focus of ongoing work will be applying this newly developed benchmarking tool to address the particular case of how much impact on emissions would come from implementing eco-driving in automated vehicles in a city, depending on what percentage of such vehicles are actually deployed.

But Wu adds that “rather than making something that can deploy eco-driving at a city scale, the main goal of this study is to support the development of general-purpose deep reinforcement learning algorithms, that can be applied to this application, but also to all these other applications — autonomous driving, video games, security problems, robotics problems, warehousing, classical control problems.”

Wu adds that “the project’s goal is to provide this as a tool for researchers, that’s openly available.” IntersectionZoo, and the documentation on how to use it, are freely available at GitHub.

Wu is joined on the paper by lead authors Vindula Jayawardana, a graduate student in MIT’s Department of Electrical Engineering and Computer Science (EECS); Baptiste Freydt, a graduate student from ETH Zurich; and co-authors Ao Qu, a graduate student in transportation; Cameron Hickert, an IDSS graduate student; and Zhongxia Yan PhD ’24. 

New molecular label could lead to simpler, faster tuberculosis tests

MIT Latest News - Mon, 05/05/2025 - 3:00pm

Tuberculosis, the world’s deadliest infectious disease, is estimated to infect around 10 million people each year, and kills more than 1 million annually. Once established in the lungs, the bacteria’s thick cell wall helps it to fight off the host immune system.

Much of that cell wall is made from complex sugar molecules known as glycans, but it’s not well-understood how those glycans help to defend the bacteria. One reason for that is that there hasn’t been an easy way to label them inside cells.

MIT chemists have now overcome that obstacle, demonstrating that they can label a glycan called ManLAM using an organic molecule that reacts with specific sulfur-containing sugars. These sugars are found in only three bacterial species, the most notorious and prevalent of which is Mycobacterium tuberculosis, the microbe that causes TB.

After labeling the glycan, the researchers were able to visualize where it is located within the bacterial cell wall, and to study what happens to it throughout the first few days of tuberculosis infection of host immune cells.

The researchers now hope to use this approach to develop a diagnostic that could detect TB-associated glycans, either in culture or in a urine sample, which could offer a cheaper and faster alternative to existing diagnostics. Chest X-rays and molecular diagnostics are very accurate but are not always available in developing nations where TB rates are high. In those countries, TB is often diagnosed by culturing microbes from a sputum sample, but that test has a high false negative rate, and it can be difficult for some patients, especially children, to provide a sputum sample. This test also requires many weeks for the bacteria to grow, delaying diagnosis.

“There aren’t a lot of good diagnostic options, and there are some patient populations, including children, who have a hard time giving samples that can be analyzed. There’s a lot of impetus to develop very simple, fast tests,” says Laura Kiessling, the Novartis Professor of Chemistry at MIT and the senior author of the study.

MIT graduate student Stephanie Smelyansky is the lead author of the paper, which appears this week in the Proceedings of the National Academy of Sciences. Other authors include Chi-Wang Ma, an MIT postdoc; Victoria Marando PhD ’23; Gregory Babunovic, a postdoc at the Harvard T.H. Chan School of Public Health; So Young Lee, an MIT graduate student; and Bryan Bryson, an associate professor of biological engineering at MIT.

Labeling glycans

Glycans are found on the surfaces of most cells, where they perform critical functions such as mediating communication between cells.In bacteria, glycans help the microbes to enter host cells, and they also appear to communicate with the host immune system, in some cases blocking the immune response.

Mycobacterium tuberculosis has a really elaborate cell envelope compared to other bacteria, and it’s a rich structure that’s composed of a lot of different glycans,” Smelyansky says. “Something that’s often underappreciated is the fact that these glycans can also interact with our host cells. When our immune cells recognize these glycans, instead of sending out a danger signal, it can send the opposite message, that there’s no danger.”

Glycans are notoriously difficult to tag with any kind of probe, because unlike proteins or DNA, they don’t have distinctive sequences or chemical reactivities that can be targeted. And unlike proteins, they are not genetically encoded, so cells can’t be genetically engineered to produce sugars labeled with fluorescent tags such as green fluorescent protein.

One of the key glycans in M. tuberculosis, known as ManLAM, contains a rare sugar known as MTX, which is unusual in that it has a thioether — a sulfur atom sandwiched between two carbon atoms. This chemical group presented an opportunity to use a small-molecule tag that had been previously developed for labeling methionine, an  amino acid that contains a similar group.

The researchers showed that they could use this tag, known as an oxaziridine, to label ManLAM in M. tuberculosis. The researchers linked the oxaziridine to a fluorescent probe and showed that in M. tuberculosis, this tag showed up in the outer layer of the cell wall. When the researchers exposed the label to Mycobacterium smegmatis, a related bacterium that does not cause disease and does not have the sugar MTX, they saw no fluorescent signal.

“This is the first approach that really selectively allows us to visualize one glycan in particular,” Smelyansky says.

Better diagnostics

The researchers also showed that after labeling ManLAM in M. tuberculosis cells, they could track the cells as they infected immune cells called macrophages. Some tuberculosis researchers had hypothesized that the bacterial cells shed ManLAM once inside a host cell, and that those free glycans then interact with the host immune system. However, the MIT team found that the glycan appears to remain in the bacterial cell walls for at least the first few days of infection.

“The bacteria still have their cell walls attached to them. So it may be that some glycan is being released, but the majority of it is retained on the bacterial cell surface, which has never been shown before,” Smelyansky says.

The researchers now plan to use this approach to study what happens to the bacteria following treatment with different antibiotics, or immune stimulation of the macrophages. It could also be used to study in more detail how the bacterial cell wall is assembled, and how ManLAM helps bacteria get into macrophages and other cells.

“Having a handle to follow the bacteria is really valuable, and it will allow you to visualize processes, both in cells and in animal models, that were previously invisible,” Kiessling says.

She also hopes to use this approach to create new diagnostics for tuberculosis. There is currently a diagnostic in development that uses antibodies to detect ManLAM in a urine sample. However, this test only works well in patients with very active cases of TB, especially people who are immunosuppressed because of HIV or other conditions.

Using their small-molecule sensor instead of antibodies, the MIT team hopes to develop a more sensitive test that could detect ManLAM in the urine even when only small quantities are present.

“This is a beautifully elegant approach to selectively label the surface of mycobacteria, enabling real-time monitoring of cell wall dynamics in this important bacterial family. Such investigations will inform the development of novel strategies to diagnose, prevent, and treat mycobacterial disease, most notably tuberculosis, which remains a global health challenge,” says Todd Lowary, a distinguished research fellow at the Institute of Biological Chemistry, Academia Sinica, Taipei Taiwan, who was not involved in the research.

The research was funded by the National Institute of Allergy and Infectious Disease, the National Institutes of Health, the National Science Foundation, and the Croucher Fellowship.

Another Move in the Deepfake Creation/Detection Arms Race

Schneier on Security - Mon, 05/05/2025 - 12:02pm

Deepfakes are now mimicking heartbeats

In a nutshell

  • Recent research reveals that high-quality deepfakes unintentionally retain the heartbeat patterns from their source videos, undermining traditional detection methods that relied on detecting subtle skin color changes linked to heartbeats.
  • The assumption that deepfakes lack physiological signals, such as heart rate, is no longer valid. This challenges many existing detection tools, which may need significant redesigns to keep up with the evolving technology.
  • To effectively identify high-quality deepfakes, researchers suggest shifting focus from just detecting heart rate signals to analyzing how blood flow is distributed across different facial regions, providing a more accurate detection strategy...

EPA reorganization signals end to climate work

ClimateWire News - Mon, 05/05/2025 - 6:14am
The agency plans to eliminate offices that track planet-warming emissions and regulate air pollution.

Stronger flood standards coming for new hospitals, schools, apartments

ClimateWire News - Mon, 05/05/2025 - 6:12am
The requirements earned initial approval last week from the International Code Council.

Puerto Rico drops $1B climate lawsuit as Trump targets state cases

ClimateWire News - Mon, 05/05/2025 - 6:11am
The move came days after the Justice Department sued two states over their legal challenges against the oil and gas industry.

Warren Buffett calls for grid overhaul in his CEO swan song

ClimateWire News - Mon, 05/05/2025 - 6:11am
The legendary investor said the U.S. electric grid needs "incredible improvement" during his last shareholder meeting as Berkshire Hathaway chief executive.

US wins extradition for accused hacker of climate activists

ClimateWire News - Mon, 05/05/2025 - 6:10am
Documents stolen by a worldwide hacking ring were cited by Exxon Mobil in court as it battled a series of climate lawsuits.

Trump targets LIHEAP as more people use it to stay cool

ClimateWire News - Mon, 05/05/2025 - 6:08am
The administration said in its proposed budget that the Low-Income Home Energy Assistance Program is "unnecessary."

LA homeowners begin to rebuild after devastating wildfires

ClimateWire News - Mon, 05/05/2025 - 6:08am
Some 17,000 homes, businesses and other structures burned to the ground in the January fires. It’s uncertain how much will be rebuilt.

Investors with $1.6T seek reassurance from European bank on net-zero push

ClimateWire News - Mon, 05/05/2025 - 6:07am
HSBC Holdings has walked back some of its emissions goals, a move it said was necessary because of the slow pace of decarbonization in the wider economy.

Climate adaptation to top $4T in sales by 2050, says report

ClimateWire News - Mon, 05/05/2025 - 6:06am
Companies offering adaptation are “emerging as a complementary and increasingly investable part of the broader climate response,” the report says.

Net-zero flights will hinge on green fuels, Air New Zealand says

ClimateWire News - Mon, 05/05/2025 - 6:05am
The airline remains committed to achieving net-zero carbon emissions by 2050 and sees potential to accelerate its interim goals.

MIT physicists snap the first images of “free-range” atoms

MIT Latest News - Mon, 05/05/2025 - 12:00am

MIT physicists have captured the first images of individual atoms freely interacting in space. The pictures reveal correlations among the “free-range” particles that until now were predicted but never directly observed. Their findings, appearing today in the journal Physical Review Letters, will help scientists visualize never-before-seen quantum phenomena in real space.

The images were taken using a technique developed by the team that first allows a cloud of atoms to move and interact freely. The researchers then turn on a lattice of light that briefly freezes the atoms in their tracks, and apply finely tuned lasers to quickly illuminate the suspended atoms, creating a picture of their positions before the atoms naturally dissipate.

The physicists applied the technique to visualize clouds of different types of atoms, and snapped a number of imaging firsts. The researchers directly observed atoms known as “bosons,” which bunched up in a quantum phenomenon to form a wave. They also captured atoms known as “fermions” in the act of pairing up in free space — a key mechanism that enables superconductivity.

“We are able to see single atoms in these interesting clouds of atoms and what they are doing in relation to each other, which is beautiful,” says Martin Zwierlein, the Thomas A. Frank Professor of Physics at MIT.

In the same journal issue, two other groups report using similar imaging techniques, including a team led by Nobel laureate Wolfgang Ketterle, the John D. MacArthur Professor of Physics at MIT. Ketterle’s group visualized enhanced pair correlations among bosons, while the other group, from École Normale Supérieure in Paris, led by Tarik Yefsah, a former postdoc in Zwierlein’s lab, imaged a cloud of noninteracting fermions.

The study by Zwierlein and his colleagues is co-authored by MIT graduate students Ruixiao Yao, Sungjae Chi, and Mingxuan Wang, and MIT assistant professor of physics Richard Fletcher.

Inside the cloud

A single atom is about one-tenth of a nanometer in diameter, which is one-millionth of the thickness of a strand of human hair. Unlike hair, atoms behave and interact according to the rules of quantum mechanics; it is their quantum nature that makes atoms difficult to understand. For example, we cannot simultaneously know precisely where an atom is and how fast it is moving.

Scientists can apply various methods to image individual atoms, including absorption imaging, where laser light shines onto the atom cloud and casts its shadow onto a camera screen.

“These techniques allow you to see the overall shape and structure of a cloud of atoms, but not the individual atoms themselves,” Zwierlein notes. “It’s like seeing a cloud in the sky, but not the individual water molecules that make up the cloud.”

He and his colleagues took a very different approach in order to directly image atoms interacting in free space. Their technique, called “atom-resolved microscopy,” involves first corralling a cloud of atoms in a loose trap formed by a laser beam. This trap contains the atoms in one place where they can freely interact. The researchers then flash on a lattice of light, which freezes the atoms in their positions. Then, a second laser illuminates the suspended atoms, whose fluorescence reveals their individual positions.

“The hardest part was to gather the light from the atoms without boiling them out of the optical lattice,” Zwierlein says. “You can imagine if you took a flamethrower to these atoms, they would not like that. So, we’ve learned some tricks through the years on how to do this. And it’s the first time we do it in-situ, where we can suddenly freeze the motion of the atoms when they’re strongly interacting, and see them, one after the other. That’s what makes this technique more powerful than what was done before.”

Bunches and pairs

The team applied the imaging technique to directly observe interactions among both bosons and fermions. Photons are an example of a boson, while electrons are a type of fermion. Atoms can be bosons or fermions, depending on their total spin, which is determined by whether the total number of their protons, neutrons, and electrons is even or odd. In general, bosons attract, whereas fermions repel.

Zwierlein and his colleagues first imaged a cloud of bosons made up of sodium atoms. At low temperatures, a cloud of bosons forms what’s known as a Bose-Einstein condensate — a state of matter where all bosons share one and the same quantum state. MIT’s Ketterle was one of the first to produce a Bose-Einstein condensate, of sodium atoms, for which he shared the 2001 Nobel Prize in Physics.

Zwierlein’s group now is able to image the individual sodium atoms within the cloud, to observe their quantum interactions. It has long been predicted that bosons should “bunch” together, having an increased probability to be near each other. This bunching is a direct consequence of their ability to share one and the same quantum mechanical wave. This wave-like character was first predicted by physicist Louis de Broglie. It is the “de Broglie wave” hypothesis that in part sparked the beginning of modern quantum mechanics.

“We understand so much more about the world from this wave-like nature,” Zwierlein says. “But it’s really tough to observe these quantum, wave-like effects. However, in our new microscope, we can visualize this wave directly.”

In their imaging experiments, the MIT team were able to see, for the first time in situ, bosons bunch together as they shared one quantum, correlated de Broglie wave. The team also imaged a cloud of two types of lithium atoms. Each type of atom is a fermion, that naturally repels its own kind, but that can strongly interact with other particular fermion types. As they imaged the cloud, the researchers observed that indeed, the opposite fermion types did interact, and formed fermion pairs — a coupling that they could directly see for the first time.

“This kind of pairing is the basis of a mathematical construction people came up with to explain experiments. But when you see pictures like these, it’s showing in a photograph, an object that was discovered in the mathematical world,” says study co-author Richard Fletcher. “So it’s a very nice reminder that physics is about physical things. It’s real.”

Going forward, the team will apply their imaging technique to visualize more exotic and less understood phenomena, such as “quantum Hall physics” — situations when interacting electrons display novel correlated behaviors in the presence of a magnetic field.

“That’s where theory gets really hairy — where people start drawing pictures instead of being able to write down a full-fledged theory because they can’t fully solve it,” Zwierlein says. “Now we can verify whether these cartoons of quantum Hall states are actually real. Because they are pretty bizarre states.”

This work was supported, in part, by National Science Foundation through the MIT-Harvard Center for Ultracold Atoms, as well as by the Air Force Office of Scientific Research, the Army Research Office, the Department of Energy, the Defense Advanced Projects Research Agency, a Vannevar Bush Faculty Fellowship, and the David and Lucile Packard Foundation.

The age-old problem of long-term care

MIT Latest News - Mon, 05/05/2025 - 12:00am

Caring well for the elderly is a familiar challenge. Some elderly people need close medical attention in facilities; others struggle with reduced capabilities while not wanting to leave their homes. For families, finding good care is hard and expensive, and already-burdened family members often pick up the slack.

The problem is expanding as birthrates drop while some segments of the population live longer, meaning that a growing portion of the population is elderly. In the U.S., there are currently three states currently where at least 20 percent of the population is 65 and older. (Yes, Florida is one.) But by 2050, demographic trends suggest, there will be 43 states with that profile.

In age terms, “America is becoming Florida,” quips MIT economist Jonathan Gruber. “And it’s not just America. The whole world is aging rapidly. The share of the population over 65 is growing rapidly everywhere, and within that, the share of the elderly that are over 85 is growing rapidly.”

In a new edited volume, Gruber and several other scholars explore the subject from a global perspective. The book, “Long-Term Care around the World,” is published this month by the University of Chicago Press. The co-editors are Gruber, the Ford Professor of Economics and chair of the Department of Economics at MIT; and Kathleen McGarry, a professor of economics at Stony Brook University.

The book looks at 10 relatively wealthy countries and how they approach the problem of long-term care. In their chapter about the U.S., Gruber and McGarry emphasize a remarkable fact: About one-third of long-term care for the elderly in the U.S. is informal, provided by family and friends, despite limited time and resources. Overall, long-term care is 2 percent of U.S. GDP.

“We have two fundamental long-term care problems in the U.S.,” Gruber says. “Too much informal care at home, and, relatedly, not enough options for elders to live with effective care in ‘congregate housing’ [or elder communities], even if they’re not sick enough for a nursing facility.”

The nature of the problem

The needs of the elderly sit in plain sight. In the U.S., about 30 percent of people 65 and over, and 60 percent of people 85 and over report limitations in basic activities. Getting dressed and taking baths are among the most common daily problems; shopping for groceries and managing money are also widely reported issues. Additionally, these limitations have mental health implications. About 10 percent of the elderly report depression, rising to 30 percent among those who struggle with three or more types of basic daily tasks.

Even so, the U.S. is not actually heavily dotted with nursing homes. In a country of about 330 million people, with 62 million being 65 and over, it’s unusual for an elderly person to be in one.

“We all think of nursing homes as where you go when you’re old, but there are only about 1.2 million people in nursing homes in America,” Gruber observes. “Which is a lot, but tiny compared to the share of people who are elderly in the U.S. and who have needs. Most people who have needs get them met at home.”

And while nursing homes can be costly, home care is too. Given an average U.S. salary of $23 per hour for a home health care aide, annual costs can reach six figures even with half-time care. As a result, many families simply help their elderly relatives as best they can.

Therefore, Gruber has found, we must account for the informal costs of elder care, too. Ultimately, Gruber says, informal help represents “an inefficient system of people taking care of their elderly parents at home, which is a stress on the family, and the elders don’t get enough care.”

To be sure, some people buy private long-term care insurance to defray these costs. But this is a tricky market, where insurers are concerned about “adverse selection,” people buying policies with a distinct need for them (beyond what insurers can detect). Rates therefore can seem high, and for limited, conditional benefits. Research by MIT economist Amy Finkelstein has shown that only 18 percent of long-term insurance policies are used.

“Private long-term care insurance is a market that just hasn’t worked well,” Gruber says. “It’s basically a fixed amount of money, should you meet certain conditions. And people are surprised by that, and it doesn’t meet their needs, and it’s expensive. We need a public solution.”

Congregate housing, a possible solution

Looking at long-term care internationally helps identify what those solutions might be. The U.S. does not neglect elder care, but could clearly broaden its affordable options.

“On the one hand, what jumped out at me is how normal the U.S. is,” Gruber says. “We’re in the middle of the pack in terms of the share of GDP we spend on long-term care.” However, some European countries that spend a similar share and also rely heavily on informal elder care, including Italy and Spain, have notably lower levels of GDP per capita.

Some other European countries with income levels closer to the U.S., including Germany and the Netherlands, do spend more on long-term elder care. The Netherlands tops the list by devoting about 4 percent of its GDP to this area.

However, in the U.S., the issue is not so much drastically changing how much it spends on long-term elder care, but how it spends. The Dutch have a relatively more extensive system of elder communities — the “congregate housing” for the elderly who are not desperately unwell, but simply find self-reliance increasingly hard.

“That’s the huge missing hole in the U.S. long-term care system, what do we do with people who aren’t sick enough for a nursing home, but probably shouldn’t be at home,” Gruber says. “Right now they stay at home, they’re lonely, they’re not getting services, their kids are super-stressed out, and they’re pulling millions of people out of the labor force, especially women. Everyone is unhappy about it, and they’re not growing GDP, so it’s hurting our economy and our well-being.”

Overall, then, Gruber thinks further investment in elder-care communities would be an example of effective government spending that can address the brewing crisis in long-term care — although it would require new federal legislation in a highly polarized political environment.

Could that happen? Could the U.S. invest more now and realize long-term financial benefits, while allowing working-age employees to spend more time at their jobs rather than acting as home caregivers? Making people more aware of the issue, Gruber thinks, is a necessary starting point.

“If anything might be bipartisan, it could be long-term care,” Gruber says. “Everybody has parents. A solution has to be bipartisan. Long-term care may be one of those areas where it’s possible.”

Support for the research was provided, in part, by the National Institute on Aging.

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