Researchers at the Antimicrobial Resistance (AMR) interdisciplinary research group of the Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, have developed a powerful tool capable of scanning thousands of biological samples to detect transfer ribonucleic acid (tRNA) modifications — tiny chemical changes to RNA molecules that help control how cells grow, adapt to stress, and respond to diseases such as cancer and antibiotic‑resistant infections. This tool opens up new possibilities for science, health care, and industry — from accelerating disease research and enabling more precise diagnostics to guiding the development of more effective medical treatments for diseases such as cancer and antibiotic-resistant infections.

For this study, the SMART AMR team worked in collaboration with researchers at MIT, Nanyang Technological University in Singapore, the University of Florida, the University at Albany in New York, and Lodz University of Technology in Poland.

Addressing current limitations in RNA modification profiling

Cancer and infectious diseases are complicated health conditions in which cells are forced to function abnormally by mutations in their genetic material or by instructions from an invading microorganism. The SMART-led research team is among the world’s leaders in understanding how the epitranscriptome — the over 170 different chemical modifications of all forms of RNA — controls growth of normal cells and how cells respond to stressful changes in the environment, such as loss of nutrients or exposure to toxic chemicals. The researchers are also studying how this system is corrupted in cancer or exploited by viruses, bacteria, and parasites in infectious diseases.

Current molecular methods used to study the expansive epitranscriptome and all of the thousands of different types of modified RNA are often slow, labor-intensive, costly, and involve hazardous chemicals, which limits research capacity and speed.

To solve this problem, the SMART team developed a new tool that enables fast, automated profiling of tRNA modifications — molecular changes that regulate how cells survive, adapt to stress, and respond to disease. This capability allows scientists to map cell regulatory networks, discover novel enzymes, and link molecular patterns to disease mechanisms, paving the way for better drug discovery and development, and more accurate disease diagnostics. 

Unlocking the complexity of RNA modifications

SMART’s open-access research, recently published in Nucleic Acids Research and titled “tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa,” shows that the tool has already enabled the discovery of previously unknown RNA-modifying enzymes and the mapping of complex gene regulatory networks. These networks are crucial for cellular adaptation to stress and disease, providing important insights into how RNA modifications control bacterial survival mechanisms. 

Using robotic liquid handlers, researchers extracted tRNA from more than 5,700 genetically modified strains of Pseudomonas aeruginosa, a bacterium that causes infections such as pneumonia, urinary tract infections, bloodstream infections, and wound infections. Samples were enzymatically digested and analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), a technique that separates molecules based on their physical properties and identifies them with high precision and sensitivity. 

As part of the study, the process generated over 200,000 data points in a high-resolution approach that revealed new tRNA-modifying enzymes and simplified gene networks controlling how cells respond and adapt to stress. For example, the data revealed that the methylthiotransferase MiaB, one of the enzymes responsible for tRNA modification ms2i6A, was found to be sensitive to the availability of iron and sulfur and to metabolic changes when oxygen is low. Discoveries like this highlight how cells respond to environmental stresses, and could lead to future development of therapies or diagnostics.

SMART’s automated system was specially designed to profile tRNA modifications across thousands of samples rapidly and safely. Unlike traditional methods, this tool integrates robotics to automate sample preparation and analysis, eliminating the need for hazardous chemical handling and reducing costs. This advancement increases safety, throughput, and affordability, enabling routine large-scale use in research and clinical labs.

A faster and automated way to study RNA

As the first system capable of quantitative, system‑wide profiling of tRNA modifications at this scale, the tool provides a unique and comprehensive view of the epitranscriptome — the complete set of RNA chemical modifications within cells. This capability allows researchers to validate hypotheses about RNA modifications, uncover novel biology, and identify promising molecular targets for developing new therapies.

“This pioneering tool marks a transformative advance in decoding the complex language of RNA modifications that regulate cellular responses,” says Professor Peter Dedon, co-lead principal investigator at SMART AMR, professor of biological engineering at MIT, and corresponding author of the paper. “Leveraging AMR’s expertise in mass spectrometry and RNA epitranscriptomics, our research uncovers new methods to detect complex gene networks critical for understanding and treating cancer, as well as antibiotic-resistant infections. By enabling rapid, large-scale analysis, the tool accelerates both fundamental scientific discovery and the development of targeted diagnostics and therapies that will address urgent global health challenges.”

Accelerating research, industry, and health-care applications

This versatile tool has broad applications across scientific research, industry, and health care. It enables large-scale studies of gene regulation, RNA biology, and cellular responses to environmental and therapeutic challenges. The pharmaceutical and biotech industry can harness it for drug discovery and biomarker screening, efficiently evaluating how potential drugs affect RNA modifications and cellular behavior. This aids the development of targeted therapies and personalized medical treatments.

“This is the first tool that can rapidly and quantitatively profile RNA modifications across thousands of samples,” says Jingjing Sun, research scientist at SMART AMR and first author of the paper. “It has not only allowed us to discover new RNA-modifying enzymes and gene networks, but also opens the door to identifying biomarkers and therapeutic targets for diseases such as cancer and antibiotic-resistant infections. For the first time, large-scale epitranscriptomic analysis is practical and accessible.”

Looking ahead: advancing clinical and pharmaceutical applications

Moving forward, SMART AMR plans to expand the tool’s capabilities to analyze RNA modifications in human cells and tissues, moving beyond microbial models to deepen understanding of disease mechanisms in humans. Future efforts will focus on integrating the platform into clinical research to accelerate the discovery of biomarkers and therapeutic targets. The translation of the technology into an epitranscriptome-wide analysis tool that can be used in pharmaceutical and health-care settings will drive the development of more effective and personalized treatments.

The research conducted at SMART is supported by the National Research Foundation Singapore under its Campus for Research Excellence and Technological Enterprise program.

The Interior secretary indicated that 1 degree of climate change was an acceptable consequence of ramping up fossil fuels for data centers.

Connecticut Gov. Ned Lamont said he's "happy to open up the conversation to other sources of energy, including natural gas."

The administration cites whale protection in its anti-wind agenda. But that concern vanishes for fossil fuel projects in whale habitat.

Facing legal challenges, the department dissolved the group whose members wrote a report critical of mainstream climate science.

The warnings came as the agency works to revoke the 2009 scientific finding that climate change threatens people.

Kip Lipper is at the center of state lawmakers’ gridlock on energy bills.

Geopolitical instability is forcing Europe to look to the heavens for its energy security.

Officials proposed setting up the hub as early as 2022, with firefighting aircraft that could quickly respond to wildfires in the Middle East.

Several apps help people figure out which actions create the most emissions and how to avoid them. An AP reporter tried three of them.

At MIT, a few scribbles on a whiteboard can turn into a potentially transformational cancer treatment.

This scenario came to fruition this week when the U.S. Food and Drug Administration approved a system for treating an aggressive form of bladder cancer. More than a decade ago, the system started as an idea in the lab of MIT Professor Michael Cima at the Koch Institute for Integrative Cancer Research, enabled by funding from the National Institutes of Health and MIT’s Deshpande Center.

The work that started with a few researchers at MIT turned into a startup, TARIS Biomedical LLC, that was co-founded by Cima and David H. Koch Institute Professor Robert Langer, and acquired by Johnson & Johnson in 2019. In developing the core concept of a device for local drug delivery to the bladder — which represents a new paradigm in bladder cancer treatment — the MIT team approached drug delivery like an engineering problem.

“We spoke to urologists and sketched out the problems with past treatments to get to a set of design parameters,” says Cima, a David H. Koch Professor of Engineering and professor of materials science and engineering. “Part of our criteria was it had to fit into urologists’ existing procedures. We wanted urologists to know what to do with the system without even reading the instructions for use. That’s pretty much how it came out.”

To date, the system has been used in patients thousands of times. In one study involving people with high-risk, non-muscle-invasive bladder cancer whose disease had proven resistant to standard care, doctors could find no evidence of cancer in 82.4 percent of patients treated with the system. More than 50 percent of those patients were still cancer-free nine months after treatment.

The results are extremely gratifying for the team of researchers that worked on it at MIT, including Langer and Heejin Lee SM ’04, PhD ’09, who developed the system as part of his PhD thesis. And Cima says far more people deserve credit than just the ones who scribbled on his whiteboard all those years ago.

“Drug products like this take an enormous amount of effort,” says Cima. “There are probably more than 1,000 people that have been involved in developing and commercializing the system: the MIT inventors, the urologists they consulted, the scientists at TARIS, the scientists at Johnson & Johnson — and that’s not including all the patients who participated in clinical trials. I also want to emphasize the importance of the MIT ecosystem, and the importance of giving people the resources to pursue arguably crazy ideas. We need to continue to support those kinds of activities.”

In the mid 2000s, Langer connected Cima with a urologist at Boston Children’s Hospital who was seeking a new treatment for a painful bladder disease known as interstitial cystitis. The standard treatment required frequent drug infusions into a patient’s bladder through a catheter, which provided only temporary relief.

A group of researchers including Cima; Lee; Hong Linh Ho Duc SM ’05, PhD ’09; Grace Kim PhD ’08; and Karen Daniel PhD ’09 began speaking with urologists and people who had run failed clinical trials involving bladder treatments to understand what went wrong. All that information went on Cima’s whiteboard over the course of several weeks. Fortunately, Cima also scribbled “Do not erase!”

“We learned a lot in the process of writing everything down,” Cima says. “We learned what not to build and what to avoid.”

With the problem well-defined, Cima received a grant from MIT’s Deshpande Center for Technological Innovation, which allowed Lee to work on designing a better solution as part of his PhD thesis.

One of the key advances the group made was using a special alloy that gave the device “shape memory” so that it could be straightened out and inserted into the bladder through a catheter. Then it would fold up, preventing it from being expelled during urination.

The new design was able to slowly release drugs over a two-week period — far longer than any other approach — and could then be removed using a thin, flexible tube commonly used in urology, called a cystoscope. The progress was enough for Cima and Langer, who are both serial entrepreneurs, to found TARIS Biomedical and license the technology from MIT. Lee and three other MIT graduates joined the company.

“It was a real pleasure working with Mike Cima, our students, and colleagues on this novel drug delivery system, which is already changing patients’ lives,” Langer says, “It’s a great example of how research at the Koch Institute starts with basic science and engineering and ends up with new treatments for cancer patients.”

The FDA’s approval of the system for the treatment of certain patients with high-risk, non-muscle-invasive bladder cancer now means that patients with this disease may have a better treatment option. Moving forward, Cima hopes the system continues to be explored to treat other diseases.

Everyone gets headaches. But not everyone gets cluster headache attacks, a debilitating malady producing acute pain that lasts an hour or two. Cluster headache attacks come in sets — hence the name — and leave people in complete agony, unable to function. A little under 1 percent of the U.S. population suffers from cluster headache.

But that’s just an outline of the matter. What’s it like to actually have a cluster headache?

“The pain of a cluster headache is such that you can’t sit still,” says MIT-based science journalist Tom Zeller, who has suffered from them for decades. “I’d liken it to putting your hand on a hot burner, except that you can’t take your hand off for an hour or two. Every headache is an emergency. You have to run or pace or rock. Think of another pain you had to dance through, but it just doesn’t stop. It’s that level of intensity, and it’s all happening inside your head.”

And then there is the pain of the migraine headache, which seems slightly less acute than a cluster attack, but longer-lasting, and similarly debilitating. Migraine attacks can be accompanied by extreme sensitivity to light and noise, vision issues, and nausea, among other neurological symptoms, leaving patients alone in dark rooms for hours or days. An estimated 1.2 billion people around the world, including 40 million in the U.S., struggle with migraine attacks.

These are not obscure problems. And yet: We don’t know exactly why migraine and cluster headache disorders occur, nor how to address them. Headaches have never been a prominent topic within modern medical research. How can something so pervasive be so overlooked?

Now Zeller examines these issues in an absorbing book, “The Headache: The Science of a Most Confounding Affliction — and a Search for Relief,” published this summer by Mariner Books. Zeller is the editor-in-chief and co-founder of Undark, a digital magazine on science and society published by the Knight Science Journalism Program at MIT.

One word, but different syndromes

“The Headache,” which is Zeller’s first book, combines a first-person narrative of his own suffering, accounts of the pain and dread that other headache sufferers feel, and thorough reporting on headache-based research in science and medicine. Zeller has experienced cluster headache attacks for 30-plus years, dating to when he was in his 20s.

“In some ways, I suppose I had been writing the book my whole adult life without knowing it,” Zeller says. Indeed, he had collected research material about these conditions for years while grappling with his own headache issues.

A key issue in the book is why society has not taken cluster headache and migraine problems more seriously — and relatedly, why the science of headache disorders is not more advanced. Although in fairness, as Zeller says, “Anything involving the brain or central nervous system is incredibly hard to study.”

More broadly, Zeller suggests in the book, we have conflated regular workaday headaches — the kind you may get from staring at a screen too long — with the far more severe and rather different disorders like cluster headache and migraine. (Some patients refer to cluster headache and migraine in the singular, not plural, to emphasize that this is an ongoing condition, not just successive headaches.)

“Headaches are annoying, and we tough it out,” Zeller says. “But we use the same exact word to talk about these other things,” namely, cluster headache and migraine. This has likely reinforced our general dismissal of severe headache disorders as a pressing and distinct medical problem. Instead, we often consider headache disorders, even severe ones, as something people should simply power through.

“There’s a certain sense of malingering we still attach to a migraine or [other] headache disorder, and I’m not sure that’s going away,” Zeller says.

Then too, about three-quarters of people who experience migraine attacks are women, which has quite plausibly led the ailment to “get short shrift historically,” as Zeller says. Or at least, in recent history: As Zeller chronicles in the book, an awareness of severe headache disorders goes back to ancient times, and it’s possible they have received less relative attention in modernity.

A new shift in medical thinking

In any case, for much of the 20th century, conventional medical wisdom held that migraine and cluster headache stemmed from changes or abnormalities in blood vessels. But in recent decades, as Zeller details, there has been a paradigm shift: These conditions are now seen as more neurological in origin.

A key breakthrough here was the 1980s discovery of a neurotransmitter called calcitonin gene-related peptide, or CGRP. As scientists have discovered, CGRP is released from nerve endings around blood vessels and helps produce migraine symptoms. This offered a new strategy — and target — for combating severe head pain. The first drugs to inhibit the effects of CGRP hit the market in 2018, and most researchers in the field are now focused on idiopathic headache as a neurological disorder, not a vascular problem.

“It’s the way science works,” Zeller says. “Changing course is not easy. It’s like turning a ship on a dime. The same applies to the study of headaches.”

Many medications aimed at blocking these neurotransmitters have since been developed, though only about 20 percent of patients seem to find permanent relief as a result. As Zeller chronicles, other patients feel benefits for about a year, before the effects of a medication wear off; many of them now try complicated combinations of medications.

Severe headache disorders also seem linked to hormonal changes in people, who often see an onset of these ailments in their teens, and a diminishing of symptoms later in life. So, while headache medicine has witnessed a recent breakthrough, much more work lies ahead.

Opening up a discussion

Amid all this, one set of questions still tugging at Zeller is evolutionary in nature: Why do humans experience headache disorders at all? There is no clear evidence that other species get severe headaches — or that the prevalence of severe headache conditions in society has ever diminished.

One hypothesis, Zeller notes, is that “having a highly attuned nervous system could have been a benefit in our more primitive state.” Such a system may have helped us survive, in the past, but at the cost of producing intense disorders in some people when the wiring goes a bit awry. We may learn more about this as neuro-based headache research continues.

“The Headache” has received widespread praise. Writing in The New Yorker, Jerome Groopman heralded the “rich material in the book,” noting that it “weaves together history, biology, a survey of current research, testimony from patients, and an agonizing account of Zeller’s own suffering.”

For his part, Zeller says he is appreciative of the attention “The Headache” has generated, as one of the most widely-noted nonfiction books released this summer.

“It’s opened up room for a kind of conversation that doesn’t usually break through into the mainstream,” Zeller says. “I’m hearing from a lot of patients who just are saying, ‘Thank you for writing this.’ And that’s really gratifying. I’m most happy to hear from people who think it’s giving them a voice. I’m also hearing a lot from doctors and scientists. The moment has opened up for this discussion, and I’m grateful for that.”

Nature Climate Change, Published online: 11 September 2025; doi:10.1038/s41558-025-02434-7

The role of climate science is changing — fast. Once positioned to inform policy, scientific assessments are increasingly being used in courtrooms to substantiate claims of harm, causation and state responsibility. Climate knowledge has now become legal evidence in the fight for climate justice.

Nature Climate Change, Published online: 11 September 2025; doi:10.1038/s41558-025-02428-5

How evapotranspiration changes with warming is not well understood. Here the authors show that when often-neglected land–atmosphere feedbacks are considered, evapotranspiration increases less than currently projected by offline models.

If the Supreme Court doesn’t reverse a lower court’s ruling, internet service providers (ISPs) could be forced to terminate people’s internet access based on nothing more than mere accusations of copyright infringement. This would threaten innocent users who rely on broadband for essential aspects of daily life. EFF—along with the American Library Association, the Association of Research Libraries, and Re:Create—filed an amicus brief urging the Court to reverse the decision.

The Stakes: Turning ISPs into Copyright Police

Among other things, the Supreme Court approving the appeals court’s findings will radically change the amount of risk your ISP takes on if a customer infringes on copyright, forcing the ISP to terminate access to the internet for those users accused of copyright infringement—and everyone else who uses that internet connection.

This issue turns on what courts call “secondary liability,” which is the legal idea that someone can be held responsible not for what they did directly, but for what someone else did using their product or service.

The case began when music companies sued Cox Communications, arguing that the ISP should be held liable for copyright infringement committed by some of its subscribers. The Court of Appeals for the Fourth Circuit agreed, adopting a “material contribution” standard for contributory copyright liability (a rule for when service providers can be held liable for the actions of users). The lower court said that providing a service that could be used for infringement is enough to create liability when a customer infringes.

In the Patent Act, where Congress has explicitly defined secondary liability, there’s a different test: contributory infringement exists only where a product is incapable of substantial non-infringing use. Internet access, of course, is overwhelmingly used for lawful purposes, making it the very definition of a “staple article of commerce” that can’t be liable under the patent framework. Yet under the Fourth Circuit’s rule, ISPs could face billion-dollar damages if they fail to terminate users on the basis of even flimsy or automated infringement claims.

Our Argument: Apply Clear Rules from the Patent Act, Not Confusing Judge-Made Tests

Our brief urges the Court to do what it has done in the past: look to patent law to define the limits of secondary liability in copyright. That means contributory infringement must require more than a “material contribution” by the service provider—it should apply only when a product or service is especially designed for infringement and lacks substantial non-infringing uses.

The Human Cost: Losing Internet Access Hurts Everyone

The Fourth Circuit’s rule threatens devastating consequences for the public. Terminating an ISP account doesn’t just affect a person accused of unauthorized file sharing—it cuts off entire households, schools, libraries, or businesses that share an internet connection.

• Public libraries, which provide internet access to millions of Americans who lack it at home, could lose essential service.
• Universities, hospitals, and local governments could see internet access for whole communities disrupted.
• Households—especially in low-income and communities of color, which disproportionately share broadband connections with other people—would face collective punishment for the alleged actions of a single user.

With more than a third of Americans having only one or no broadband provider, many users would have no way to reconnect once cut off. And given how essential internet access is for education, employment, healthcare, and civic participation, the consequences of termination are severe and disproportionate.

What’s Next

The Supreme Court has an opportunity to correct course. We’re asking the Court to reject the Fourth Circuit’s unfounded “material contribution” test, reaffirm that patent law provides the right framework for secondary liability, and make clear that the Constitution requires copyright to serve the public good. The Court should ensure that copyright enforcement doesn’t jeopardize the internet access on which participation in modern life depends.

We’ll be watching closely as the Court considers this case. In the meantime, you can read our amicus brief here.

Whether you’re an artist, advertising specialist, or just looking to spruce up your home, turning everyday objects into dynamic displays is a great way to make them more visually engaging. For example, you could turn a kids’ book into a handheld cartoon of sorts, making the reading experience more immersive and memorable for a child.

But now, thanks to MIT researchers, it’s also possible to make dynamic displays without using electronics, using barrier-grid animations (or scanimations), which use printed materials instead. This visual trick involves sliding a patterned sheet across an image to create the illusion of a moving image. The secret of barrier-grid animations lies in its name: An overlay called a barrier (or grid) often resembling a picket fence moves across, rotates around, or tilts toward an image to reveal frames in an animated sequence. That underlying picture is a combination of each still, sliced and interwoven to present a different snapshot depending on the overlay’s position.

While tools exist to help artists create barrier-grid animations, they’re typically used to create barrier patterns that have straight lines. Building off of previous work in creating images that appear to move, researchers at MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) have developed a tool that allows users to explore more unconventional designs. From zigzags to circular patterns, the team’s “FabObscura” software turns unique concepts into printable scanimations, helping users add dynamic animations to things like pictures, toys, and decor.

MIT Department of Electrical Engineering and Computer Science (EECS) PhD student and CSAIL researcher Ticha Sethapakdi SM ’19, a lead author on a paper presenting FabObscura, says that the system is a one-size-fits-all tool for customizing barrier-grid animations. This versatility extends to unconventional, elaborate overlay designs, like pointed, angled lines to animate a picture you might put on your desk, or the swirling, hypnotic appearance of a radial pattern you could spin over an image placed on a coin or a Frisbee.

“Our system can turn a seemingly static, abstract image into an attention-catching animation,” says Sethapakdi. “The tool lowers the barrier to entry to creating these barrier-grid animations, while helping users express a variety of designs that would’ve been very time-consuming to explore by hand.”

Behind these novel scanimations is a key finding: Barrier patterns can be expressed as any continuous mathematical function — not just straight lines. Users can type these equations into a text box within the FabObscura program, and then see how it graphs out the shape and movement of a barrier pattern. If you wanted a traditional horizontal pattern, you’d enter in a constant function, where the output is the same no matter the input, much like drawing a straight line across a graph. For a wavy design, you’d use a sine function, which is smooth and resembles a mountain range when plotted out. The system’s interface includes helpful examples of these equations to guide users toward their preferred pattern.

A simple interface for elaborate ideas

FabObscura works for all known types of barrier-grid animations, supporting a variety of user interactions. The system enables the creation of a display with an appearance that changes depending on your viewpoint. FabObscura also allows you to create displays that you can animate by sliding or rotating a barrier over an image.

To produce these designs, users can upload a folder of frames of an animation (perhaps a few stills of a horse running), or choose from a few preset sequences (like an eye blinking) and specify the angle your barrier will move. After previewing your design, you can fabricate the barrier and picture onto separate transparent sheets (or print the image on paper) using a standard 2D printer, such as an inkjet. Your image can then be placed and secured on flat, handheld items such as picture frames, phones, and books.

You can enter separate equations if you want two sequences on one surface, which the researchers call “nested animations.” Depending on how you move the barrier, you’ll see a different story being told. For example, CSAIL researchers created a car that rotates when you move its sheet vertically, but transforms into a spinning motorcycle when you slide the grid horizontally.

These customizations lead to unique household items, too. The researchers designed an interactive coaster that you can switch from displaying a “coffee” icon to symbols of a martini and a glass of water by pressing your fingers down on the edges of its surface. The team also spruced up a jar of sunflower seeds, producing a flower animation on the lid that blooms when twisted off.

Artists, including graphic designers and printmakers, could also use this tool to make dynamic pieces without needing to connect any wires. The tool saves them crucial time to explore creative, low-power designs, such as a clock with a mouse that runs along as it ticks. FabObscura could produce animated food packaging, or even reconfigurable signage for places like construction sites or stores that notify people when a particular area is closed or a machine isn’t working.

Keep it crisp

FabObscura’s barrier-grid creations do come with certain trade-offs. While nested animations are novel and more dynamic than a single-layer scanimation, their visual quality isn’t as strong. The researchers wrote design guidelines to address these challenges, recommending users upload fewer frames for nested animations to keep the interlaced image simple and stick to high-contrast images for a crisper presentation.

In the future, the researchers intend to expand what users can upload to FabObscura, like being able to drop in a video file that the program can then select the best frames from. This would lead to even more expressive barrier-grid animations.

FabObscura might also step into a new dimension: 3D. While the system is currently optimized for flat, handheld surfaces, CSAIL researchers are considering implementing their work into larger, more complex objects, possibly using 3D printers to fabricate even more elaborate illusions.

Sethapakdi wrote the paper with several CSAIL affiliates: Zhejiang University PhD student and visiting researcher Mingming Li; MIT EECS PhD student Maxine Perroni-Scharf; MIT postdoc Jiaji Li; MIT associate professors Arvind Satyanarayan and Justin Solomon; and senior author and MIT Associate Professor Stefanie Mueller, leader of the Human-Computer Interaction (HCI) Engineering Group at CSAIL. Their work will be presented at the ACM Symposium on User Interface Software and Technology (UIST) this month.

Kresge Auditorium came alive Friday as MIT entrepreneurs took center stage to share their progress in the delta v startup accelerator program.

Now in its 14th year, delta v Demo Day represents the culmination of a summer in which students work full-time on new ventures under the guidance of the Martin Trust Center for MIT Entrepreneurship.

It also doubles as a celebration, with Trust Center Managing Director (and consummate hype man) Bill Aulet setting the tone early with his patented high-five run through the audience and leap on stage for opening remarks.

“All these students have performed a miracle,” Aulet told the crowd. “One year ago, they were sitting in the audience like all of you. One year ago, they probably didn’t even have an idea or a technology. Maybe they did, but they didn’t have a team, a clear vision, customer models, or a clear path to impact. But today they’re going to blow your mind. They have products — real products — a founding team, a clear mission, customer commitments or letters of intent, legitimate business models, and a path to greatness and impact. In short, they will have achieved escape velocity.”

The two-hour event filled Kresge Auditorium, with a line out the door for good measure, and was followed by a party under a tent on the Kresge lawn. Each presentation began with a short video introducing the company before a student took the stage to expand on the problem they were solving and what their team has learned from talks with potential customers.

In total, 22 startups showcased their ventures and early business milestones in rapid-fire presentations.

Rick Locke, the new dean of the MIT Sloan School of Management, said events like Demo Day are why he came back to the Institute after serving in various roles between 1988 and 2013.

“What’s great about this event is how it crystallizes the spirit of MIT: smart people doing important work, doing it by rolling up their sleeves, doing it with a certain humility but also a vision, and really making a difference in the world,” Locke told the audience. “You can feel the positivity, the energy, and the buzz here tonight. That’s what the world needs more of.”

A program with a purpose

This year’s Demo Day featured 70 students from across MIT, with 16 startups working out of the Trust Center on campus and six working from New York City. Through the delta v program, the students were guided by mentors, received funding, and worked through an action-oriented curriculum full-time between June and September. Aulet also noted that the students presenting benefitted from entrepreneurial support resources from across the Institute.

The odds are in the startups’ favor: A 2022 study found that 69 percent of businesses from the program were still operating five years later. Alumni companies had raised roughly $1 billion in funding.

Demo Day marks the end of delta v and serves to inspire next year’s cohort of entrepreneurs.

“Turn on a screen or look anywhere around you, and you'll see issues with climate, sustainability, health care, the future of work, economic disparities, and more,” Aulet said. “It can all be overwhelming. These entrepreneurs bring light to dark times. Entrepreneurs don’t see problems. As the great Biggie Smalls from Brooklyn said, ‘Turn a negative into a positive.’ That’s what entrepreneurs do.”

Startups in action

Startups in this year’s cohort presented solutions in biotech and health care, sustainability, financial services, energy, and more.

One company, Gees, is helping women with hormonal conditions like polycystic ovary syndrome (PCOS) with a saliva-based sensor that tracks key hormones to help women get personalized insights and manage symptoms.

“Over 200 million women live with PCOS worldwide,” said MIT postdoc and co-founder Walaa Khushaim. “If it goes unmanaged, it can lead to even more serious diseases. The good news is that 80 percent of cases can be managed with lifestyle changes. The problem is women trying to change their lifestyle are left in the dark, unsure if what they are doing is truly helping.”

Gees’ sensor is noninvasive and easier to use than current sensors that track hormones. It provides feedback in minutes from the comfort of users’ homes. The sensor connects to an app that shows results and trends to help women stay on track. The company already has more than 500 sign-ups for its wait list.

Another company, Kira, has created an electrochemical system to increase the efficiency and access of water desalination. The company is aiming to help companies manage their brine wastewater that is often dumped, pumped underground, or trucked off to be treated.

“At Kira, we’re working toward a system that produces zero liquid waste and only solid salts,” says PhD student Jonathan Bessette SM ’22.

Kira says its system increases the amount of clean water created by industrial processes, reduces the amount of brine wastewater, and optimizes the energy flows of factories. The company says next year it will deploy a system at the largest groundwater desalination plant in the U.S.

A variety of other startups presented at the event:

AutoAce builds AI agents for car dealerships, automating repetitive tasks with a 24/7 voice agent that answers inbound service calls and books appointments.

Carbion uses a thermochemical process to convert biomass into battery-grade graphite at half the temperature of traditional synthetic methods.

Clima Technologies has developed an AI building engineer that enables facilities managers to “talk” to their buildings in real-time, allowing teams to conduct 24/7 commissioning, act on fault diagnostics, minimize equipment downtime, and optimize controls.

Cognify uses AI to predict customer interactions with digital platforms, simulating customer behavior to deliver insights into which designs resonate with customers, where friction exists in user journeys, and how to build a user experience that converts.

Durability uses computer vision and AI to analyze movement, predict injury risks, and guide recovery for athletes.

EggPlan uses a simple blood test and proprietary model to assess eligibility for egg freezing with fertility clinics. If users do not have a baby, their fees are returned, making the process risk-free.

Forma Systems developed an optimization software for manufacturers to make smarter, faster decisions about things like materials use while reducing their climate impact.

Ground3d is a social impact organization building a digital tool for crowdsourcing hyperlocal environmental data, beginning with street-level documentation of flooding events in New York City. The platform could help residents with climate resilience and advocacy.

GrowthFactor helps retailers scale their footprint with a fractional real estate analyst while using an AI-powered platform to maximize their chance of commercial success.

Kyma uses AI-powered patient engagement to integrate data from wearables, smart scales, sensors, and continuous glucose monitors to track behaviors and draft physician-approved, timely reminders.

LNK Energies is solving the heavy-duty transport industry’s emissions problem with liquid organic hydrogen carriers (LOHCs): safe, room-temperature liquids compatible with existing diesel infrastructure.

Mendhai Health offers a suite of digital tools to help women improve pelvic health and rehabilitate before and after childbirth.

Nami has developed an automatic, reusable drinkware cleaning station that delivers a hot, soapy, pressurized wash in under 30 seconds.

Pancho helps restaurants improve margins with an AI-powered food procurement platform that uses real-time price comparison, dispute tracking, and smart ordering.

Qadence offers older adults a co-pilot that assesses mobility and fall risk, then delivers tailored guidance to improve balance, track progress, and extend recovery beyond the clinic.

Sensopore offers an at-home diagnostic device to help families test for everyday illnesses at home, get connected with a telehealth doctor, and have prescriptions shipped to their door, reducing clinical visits.

Spheric Bio has developed a personal occlusion device to improve a common surgical procedure used to treat strokes.

Tapestry uses conversational AI to chat with attendees before events and connect them with the right people for more meaningful conversations.

Torque automates financial analysis across private equity portfolios to help investment professionals make better strategic decisions.

Trazo helps interior designers and architects collaborate and iterate on technical drawings and 3D designs of new construction of remodeling projects.

San Francisco billionaire Chris Larsen once again has wielded his wallet to keep city residents under the eye of all-seeing police surveillance. 

The San Francisco Police Commission, the Board of Supervisors, and Mayor Daniel Lurie have signed off on Larsen’s $9.4 million gift of a new Real-Time Investigations Center. The plan involves moving the city’s existing police tech hub from the public Hall of Justice not to the city’s brand-new police headquarters but instead to a sublet in the Financial District building of Ripple Labs, Larsen’s crypto-transfer company. Although the city reportedly won’t be paying for the space, the lease reportedly cost Ripple $2.3 million and will last until December 2026. 

The deal will also include a $7.25 million gift from the San Francisco Police Community Foundation that Larsen created. Police foundations are semi-public fundraising arms of police departments that allow them to buy technology and gear that the city will not give them money for.  

In Los Angeles, the city’s police foundation got $178,000 from the company Target to pay for the services of the data analytics company Palantir to use for predictive policing. In Atlanta, the city’s police foundation funds a massive surveillance apparatus as well as the much-maligned Cop City training complex. (Despite police foundations’ insistence that they are not public entities and therefore do not need to be transparent or answer public records requests, a judge recently ordered the Atlanta Police Foundation to release documentation related to Cop City.) 

A police foundation in San Francisco brings the same concerns: that an unaccountable and untransparent fundraising arm shmoozing with corporations and billionaires would fund unpopular surveillance measures without having to reveal much to the public.  

Larsen was one of the deep pockets behind last year’s Proposition E, a ballot measure to supercharge surveillance in the city. The measure usurped the city’s 2019 surveillance transparency and accountability ordinance, which had required the SFPD to get the elected Board of Supervisors’ approval before buying and using new surveillance technology. This common-sense democratic hurdle was, apparently, a bridge too far for the SFPD and for Larsen.  

We’re no fans of real-time crime centers (RTCCs), as they’re often called elsewhere, to start with. They’re basically control rooms that pull together all feeds from a vast warrantless digital dragnet, often including automated license plate readers, fixed cameras, officers’ body-worn cameras, drones, and other sources. It’s a means of consolidating constant surveillance of the entire population, tracking everyone wherever they go and whatever they do – worrisome at any time, but especially in a time of rising authoritarianism.  

Think of what this data could do if it got into federal hands; imagine how vulnerable city residents would be subject to harassment if every move they made was centralized and recorded downtown. But you don’t have to imagine, because SFPD already has been caught sharing automated license plate reader data with out-of-state law enforcement agencies assisting in federal immigration investigations. 

We’re especially opposed to RTCCs using live feeds from non-city surveillance cameras to push that panopticon’s boundaries even wider, as San Francisco’s does. Those semi-private networks of some 15,000 cameras, already abused by SFPD to surveil lawful protests against police violence, were funded in part by – you guessed it – Chris Larsen. 

These technologies could potentially endanger San Franciscans by directing armed police at them due to reliance on a faulty algorithm or by putting already-marginalized communities at further risk of overpolicing and surveillance. But studies find that these technologies just don’t work. If the goal is to stop crime before it happens, to spare someone the hardship and the trauma of getting robbed or hurt, cameras clearly do not accomplish this. There’s plenty of footage of crime occurring that belies the idea that surveillance is an effective deterrent, and although police often look to technology as a silver bullet to fight crime, evidence suggests that it does little to alter the historic ebbs and flows of criminal activity. 

Yet now this unelected billionaire – who already helped gut police accountability and transparency rules and helped fund sketchy surveillance of people exercising their First Amendment rights – wants to bankroll, expand, and host the police’s tech nerve center. 

Policing must be a public function so that residents can control - and demand accountability and transparency from - those who serve and protect but also surveil and track us all. Being financially beholden to private interests erodes the community’s trust and control and can leave the public high and dry if a billionaire’s whims change or conflict with the will of the people. Chris Larsen could have tried to address the root causes of crime that affect our community; instead, he exercises his bank account's muscle to decide that surveillance is best for San Franciscans with less in their wallets. 

Elected officials should have said “thanks but no thanks” to Larsen and ensured that the San Francisco Police Department remained under the complete control and financial auspices of nobody except the people of San Francisco. Rich people should not be allowed to fund the further degradation of our privacy as we go about our lives in our city’s public places. Residents should carefully watch what comes next to decide for themselves whether a false sense of security is worth living under constant, all-seeing, billionaire-bankrolled surveillance. 

A little over a year ago we released Rayhunter, our open source tool designed to detect cell-site simulators. We’ve been blown away by the level of community engagement on this project. It has been installed on thousands of devices (or so we estimate, we don’t actually know since Rayhunter doesn’t have any telemetry!). We have received dozens of packet captures, hundreds of improvements, both minor and major, documentation fixes, and bug reports from our open source community. This project is a testament to the power and impact of open source and community driven counter-surveillance.  

If this is your first time hearing about Rayhunter, you can read our announcement blog post here. Or if you prefer, you can watch our DEF CON talk. In short, Rayhunter is an open source Linux program that runs on a variety of mobile hotspots (dedicated devices that use a cellular connection to give you Wi-Fi). Rayhunter’s job is to look for cell-site simulators (CSS), a tool police use to locate or identify people's cell phones, also known as IMSI catchers or Stingrays. Rayhunter analyzes the “handshakes” between your Rayhunter device and the cell towers it is connected to for behaviors consistent with that of a CSS. When it finds potential evidence of a CSS it alerts the user with an indicator on the screen and potentially a push notification to their phone.  

Understanding if CSS are being used to spy on protests is one of the main goals of the Rayhunter project. Thanks to members of our community bringing Rayhunter to dozens of protests, we are starting to get a picture of how CSS are currently being used in the US. So far Rayhunter has not turned up any evidence of cell-site simulators being used to spy on protests in the US — though we have found them in use elsewhere.  

So far Rayhunter has not turned up any evidence of cell-site simulators being used to spy on protests in the US.  

There are a couple of caveats here. First, it’s often impossible to prove a negative. Maybe Rayhunter just hasn’t been at protests where CSS have been present. Maybe our detection signatures aren’t picking up the techniques used by US law enforcement. But we’ve received reports from a lot of protests, including pro-Palestine protests, protests in Washington DC and Los Angeles, as well as the ‘No Kings’ and ‘50501’ protests all over the country. So far, we haven’t seen evidence of CSS use at any of them.  

A big part of the reason for the lack of CSS at protests could be that some courts have required a warrant for their use, and even law enforcement agencies not bound by these rulings have policies that require police to get a warrant. CSS are also costly to buy and use, requiring trained personnel to use nearly one million dollars worth of equipment.  

The fact is police also have potentially easier to use tools available. If the goal of using a CSS at a protest is to find out who was at the protest, police could use tools such as:  

• License plate readers to track the vehicles arriving and leaving at the protest. 
• Location data brokers, such as Locate X and Fog Data Science, to track the phones of protestors by their mobile advertising IDs (MAID).
• Cellebrite and other forensic extraction tools to download all the data from phones of arrested protestors if they are able to unlock those phones.  
• Geofence warrants, which require internet companies like Google to disclose the identifiers of devices within a given location at a given time.
• Facial recognition such as Clearview AI to identify all present via public or private databases of peoples faces.
• Tower dumps from phone companies, which, similar to geofence warrants, require phone companies to turn over a list of all the phones connected to a certain tower at a certain time.  

We think, due to the lack of evidence of CSS being used, protestors can worry less about CSS and more about these other techniques. Luckily, the actions one should take to protect themselves are largely the same: 

• To protect yourself against Locate X and Fog you can turn off location services on your phone (iPhone and Android). 
• To protect yourself from Cellebrite you can use a strong password, turn off biometric unlocks, and keep your phone up to date. 
• To protect against facial recognition, you can wear a mask. 
• To protect against tower dumps put your phone into airplane mode (though especially high risk individuals may want to use a Faraday bag instead). 

We feel pretty good about Rayhunter’s detection engine, though there could still be things we are missing. Some of our confidence in Rayhunter’s detection engine comes from the research we have done into how CSS work. But the majority of our confidence comes from testing Rayhunter against a commercial cell-site simulator thanks to our friends at Cape. Rayhunter detected every attack run by the commercial CSS.  

Where Rayhunter Has Detected Likely Surveillance

Rayhunter users have found potential evidence of CSS being used in the wild, though not at protests. One of the most interesting examples that triggered multiple detections and even inspired us to write some new detection rules was at a cruise port in the Turks and Caicos Islands. The person who captured this data put the packet captures online for other researchers to review. 

Rayhunter users have detected likely CSS use in the US as well. We have received reports from Chicago and New York where our “IMSI Sent without authentication” signature was triggered multiple times over the course of a couple hours and then stopped. Neither report was in the vicinity of a protest. We feel fairly confident that these reports are indicative of a CSS being present, though we don’t have any secondary evidence to back them up. 

We have received other reports that have triggered our CSS detection signatures, but the above examples are the ones we feel most confident about.  

We encourage people to keep using Rayhunter and continue bringing it to protests. Law enforcement trends can change over time and it is possible that some cities are using them more often than others (for example Fontana, California reportedly used their CSS over 300 times in two years). We also know that ICE still uses CSS and has recently renewed their contracts. Interestingly, in January, the FBI requested a warrant from the Foreign Intelligence Surveillance Court to use what was likely a CSS and was rejected. This was the first time the FBI has sought a warrant to use a CSS using the Foreign Intelligence Surveillance Act since 2015, when the Justice Department began requiring a warrant for their use. If police start using CSS to spy on protests we want to know.

There is still a lot we want to accomplish with Rayhunter, we have some future plans for the project that we are very excited to share with you in the near future, but the biggest thing we need right now is more testing outside of the United States.  

Taking Rayhunter International  

We are interested in getting Rayhunter data from every country to help us understand the global use of CSS and to refine our signatures. Just because CSS don't appear to be used to spy on protests in the US right now doesn't mean that is true everywhere. We have also seen that some signatures that work in the US are prone to false positives elsewhere (such as our 2G signature in countries that still have active 2G networks). The first device supported by Rayhunter, the Orbic hotspot, was US only, so we have very little international data. But we now have support for multiple devices! If you are interested in Rayhunter, but can’t find a device that works in your country, let us know. We recommend you consult with an attorney in your country to determine whether running Rayhunter is likely to be legally risky or outlawed in your jurisdiction.

Related Cases: Carpenter v. United States

The U.S. Department of Energy’s National Nuclear Security Administration (DOE/NNSA) recently announced that it has selected MIT to establish a new research center dedicated to advancing the predictive simulation of extreme environments, such as those encountered in hypersonic flight and atmospheric re-entry. The center will be part of the fourth phase of NNSA's Predictive Science Academic Alliance Program (PSAAP-IV), which supports frontier research advancing the predictive capabilities of high-performance computing for open science and engineering applications relevant to national security mission spaces.

The Center for the Exascale Simulation of Coupled High-Enthalpy Fluid–Solid Interactions (CHEFSI) — a joint effort of the MIT Center for Computational Science and Engineering, the MIT Schwarzman College of Computing, and the MIT Institute for Soldier Nanotechnologies (ISN) — plans to harness cutting-edge exascale supercomputers and next-generation algorithms to simulate with unprecedented detail how extremely hot, fast-moving gaseous and solid materials interact. The understanding of these extreme environments — characterized by temperatures of more than 1,500 degrees Celsius and speeds as high as Mach 25 — and their effect on vehicles is central to national security, space exploration, and the development of advanced thermal protection systems.

“CHEFSI will capitalize on MIT’s deep strengths in predictive modeling, high-performance computing, and STEM education to help ensure the United States remains at the forefront of scientific and technological innovation,” says Ian A. Waitz, MIT’s vice president for research. “The center’s particular relevance to national security and advanced technologies exemplifies MIT’s commitment to advancing research with broad societal benefit.”

CHEFSI is one of five new Predictive Simulation Centers announced by the NNSA as part of a program expected to provide up to $17.5 million to each center over five years.

CHEFSI’s research aims to couple detailed simulations of high-enthalpy gas flows with models of the chemical, thermal, and mechanical behavior of solid materials, capturing phenomena such as oxidation, nitridation, ablation, and fracture. Advanced computational models — validated by carefully designed experiments — can address the limitations of flight testing by providing critical insights into material performance and failure.

“By integrating high-fidelity physics models with artificial intelligence-based surrogate models, experimental validation, and state-of-the-art exascale computational tools, CHEFSI will help us understand and predict how thermal protection systems perform under some of the harshest conditions encountered in engineering systems,” says Raúl Radovitzky, the Jerome C. Hunsaker Professor of Aeronautics and Astronautics, associate director of the ISN, and director of CHEFSI. “This knowledge will help in the design of resilient systems for applications ranging from reusable spacecraft to hypersonic vehicles.”

Radovitzky will be joined on the center’s leadership team by Youssef Marzouk, the Breene M. Kerr (1951) Professor of Aeronautics and Astronautics, co-director of the MIT Center for Computational Science and Engineering (CCSE), and recently named the associate dean of the MIT Schwarzman College of Computing; and Nicolas Hadjiconstantinou, the Quentin Berg (1937) Professor of Mechanical Engineering and co-director of CCSE, who will serve as associate directors. The center co-principal investigators include MIT faculty members across the departments of Aeronautics and Astronautics, Electrical Engineering and Computer Science, Materials Science and Engineering, Mathematics, and Mechanical Engineering. Franklin Hadley will lead center operations, with administration and finance under the purview of Joshua Freedman. Hadley and Freedman are both members of the ISN headquarters team. 

CHEFSI expects to collaborate extensively with the DoE/NNSA national laboratories — Lawrence Livermore National Laboratory, Los Alamos National Laboratory, and Sandia National Laboratories — and, in doing so, offer graduate students and postdocs immersive research experiences and internships at these facilities.